Ostocin
Cheaper & Alternative Brands
Same generic (Capsaicin), same form (Cream)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Ostocin is indicated for the symptomatic relief of pain associated with osteoarthritis and rheumatoid arthritis.
Dosage & Administration
18 years of age and older
: Apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.
Contraindications
Capsaicin cream is contraindicated on broken or irritated skin. It is also contraindicated in patients with known hypersensitivity to capsaicin or any of the excipients used in this product.
Side Effects & Adverse Reactions
Transient burning sensation may occur during initial treatment, particularly if too much cream is used or if the frequency of administration is less than 3-4 times daily. This burning sensation generally disappears after several days of treatment.
Warnings & Precautions
Avoid taking a hot shower or bath just before or after applying Ostocin burning sensation may enhance. Hands should be washed immediately after use. Not for use under tight bandages.
Pharmacology & Mechanism of Action
Although the precise mechanism of action of Capsaicin is not fully understood, current evidence suggests that Capsaicin exerts an analgesic effect by depleting and preventing reaccumulation of Substance P in peripheral sensory neurons. Substance P is thought to be the principal chemomediator of pain impulses from the periphery to the central nervous system.
Absorption after topical application is unknown. Capsaicin content in capsicum fruit is approximately 1% therefore dietary intake of Capsaicin may range from 0.5-1mg/kg/day for a 50kg person. Application of 90 gm of Capsaicin cream 0.025% each week results in 3.21mg/day topical exposure. Assuming 100% absorption in a 50kg person, daily exposure would be 0.064mg/kg which is approximately one eighth of the above mentioned dietary intake.