18 years of age and older
: Apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.

⚠️ Contraindications

Capsaicin cream is contraindicated on broken or irritated skin. It is also contraindicated in patients with known hypersensitivity to capsaicin or any of the excipients used in this product.

⚡ Side Effects & Adverse Reactions

Transient burning sensation may occur during initial treatment, particularly if too much cream is used or if the frequency of administration is less than 3-4 times daily. This burning sensation generally disappears after several days of treatment.

🛡️ Warnings & Precautions

Avoid taking a hot shower or bath just before or after applying Ostocin burning sensation may enhance. Hands should be washed immediately after use. Not for use under tight bandages.

🔬 Pharmacology & Mechanism

Although the precise mechanism of action of Capsaicin is not fully understood, current evidence suggests that Capsaicin exerts an analgesic effect by depleting and preventing reaccumulation of Substance P in peripheral sensory neurons. Substance P is thought to be the principal chemomediator of pain impulses from the periphery to the central nervous system.
Absorption after topical application is unknown. Capsaicin content in capsicum fruit is approximately 1% therefore dietary intake of Capsaicin may range from 0.5-1mg/kg/day for a 50kg person. Application of 90 gm of Capsaicin cream 0.025% each week results in 3.21mg/day topical exposure. Assuming 100% absorption in a 50kg person, daily exposure would be 0.064mg/kg which is approximately one eighth of the above mentioned dietary intake.