Nintoin SR
Cheaper & Alternative Brands
Same generic (Nitrofurantoin), same form (Capsule (Sustained Release))
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Euronit is specifically indicated for the treatment & prophylaxis of urinary tract infections caused by susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
Dosage & Administration
Nitrofurantoin tablet (In adults):
Uncomplicated urinary tract infections
: 50-100 mg four times a day- the lower dosage level is recommended. Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
For long-term suppressive therapy
: In adults, a reduction of dosage to 50-100 mg at bedtime may be adequate.
Nitrofurantoin capsule (In adults):
Acute Uncomplicated Urinary Tract Infections (UTIs)
: 50 mg four times daily for 7 days.
Long term suppression
: 50-100 mg once a day.
Prophylaxis
: 50 mg four times daily for the duration of procedure and for three days thereafter.
Nitrofurantoin SR capsule:
Adults and Children over 12 years
: One 100 mg capsule every 12 hours for seven days.
Genito-urinary surgical prophylaxis
: One capsule twice daily on day of procedure and for next 3 days.
Nitrofurantoin suspension: Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age). The average dose of Nintoin suspension for pediatric patients are as follows-
7 to 11 kg: ½ (2.5 ml) teaspoonfuls 4 times daily.
12 to 21 kg: 1 (5 ml) teaspoonfuls 4 times daily.
22 to 30 kg: 1½ (7.5 ml) teaspoonfuls 4 times daily.
31 to 41 kg: 2 (10 ml) teaspoonfuls 4 times daily.
Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
Contraindications
Anuria, oliguria or significant impairment of renal function are contraindications. This drug is contraindicated in pregnant patients at 38-42 weeks, during labor and delivery. Nitrofurantoin is also contraindicated in those patients with known hypersensitivity to Nitrofurantoin.
Side Effects & Adverse Reactions
The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness and drowsiness.
Warnings & Precautions
If acute, sub-acute or chronic pulmonary reactions occur, Euronit should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Euronit.
Pharmacology & Mechanism of Action
Nitrofurantoin is an antibacterial agent specific for urinary tract infections. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. Nitrofurantoin inactivates or alters bacterial ribosomal proteins and other macromolecules. Nitrofurantoin has been shown to be active against the following bacteria: Gram-Positive Aerobes Staphylococcus saprophyticus, Coagulase-negative staphylococci (including Staphylococcus epidermidis), Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Group D streptococci, Viridans group streptococci. Gram-Negative Aerobes- Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, Klebsiella ozaenae.