Nep TS

N-Fenac TS 0.1% Ophthalmic Suspension:
The treatment of post-operative ocular pain and inflammation including cataract surgery
Inhibition of surgery induced miosis and
Prevention of post-operative cystoid macular edema (CME).
N-Fenac TS 0.3% Ophthalmic Suspension:
Post-operative pain and inflammation associated with cataract surgery.

Nepafenac 0.1% Sterile Ophthalmic Suspension-
For post-operative pain & inflammation:
Instill 1 drop 3 times daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period.
For surgery induced miosis
: Instill 1 drop 3 times daily 1 day before surgery & on the day of surgery.
For prevention of post-operative CME:
Instill 1 drop 3 times daily 1 day before surgery and continued on the day of surgery and through the first 6 weeks of the post-operative period.
Nepafenac 0.3% Sterile Ophthalmic Suspension-
For post-operative pain & inflammation:
Instill 1 drop once daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. An additional drop should be administered 30 to 120 minutes prior to surgery.
Use in children
: Safety and effectiveness in pediatric patients below 18 years of age have not been established.
Use in elderly patients
: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Reported side effects are foreign body sensation, lid margin crusting, ocular discomfort, ocular hyperemia etc.

N-Fenac TS should be used with caution in patients with known bleeding tendencies or who are receiving medications which may prolong bleeding time.

Nepafenac is a nonsteroidal anti-inflammatory prodrug (NSAID). After instillation in the eye, it penetrates the cornea and is converted by ocular tissue hydrolase to Amfenac, a potent nonsteroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of cyclooxygenase enzyme. This enzyme is required for prostaglandin synthesis.