Nepafenac

N-Fenac TS 0.1% Ophthalmic Suspension:
The treatment of post-operative ocular pain and inflammation including cataract surgery
Inhibition of surgery induced miosis and
Prevention of post-operative cystoid macular edema (CME).
N-Fenac TS 0.3% Ophthalmic Suspension:
Post-operative pain and inflammation associated with cataract surgery.

Nepafenac 0.1% Sterile Ophthalmic Suspension-
For post-operative pain & inflammation:
Instill 1 drop 3 times daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period.
For surgery induced miosis
: Instill 1 drop 3 times daily 1 day before surgery & on the day of surgery.
For prevention of post-operative CME:
Instill 1 drop 3 times daily 1 day before surgery and continued on the day of surgery and through the first 6 weeks of the post-operative period.
Nepafenac 0.3% Sterile Ophthalmic Suspension-
For post-operative pain & inflammation:
Instill 1 drop once daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. An additional drop should be administered 30 to 120 minutes prior to surgery.
Use in children
: Safety and effectiveness in pediatric patients below 18 years of age have not been established.
Use in elderly patients
: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Reported side effects are foreign body sensation, lid margin crusting, ocular discomfort, ocular hyperemia etc.

Nepafenac is a nonsteroidal anti-inflammatory prodrug (NSAID). After instillation in the eye, it penetrates the cornea and is converted by ocular tissue hydrolase to Amfenac, a potent nonsteroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of cyclooxygenase enzyme. This enzyme is required for prostaglandin synthesis.