Eluxan
Cheaper & Alternative Brands
Same generic (Eluxadoline), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Eluxan is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
Dosage & Administration
The recommended dose is 75 mg tablet taken orally twice daily with food. Patients who develop severe constipation for more than 4 days have to discontinue the drug. If a dose is missed, patient should take the next dose at the regular time and avoid taking two doses at a time.
Pediatric Use
: Safety and effectiveness in pediatric patients have not been established.
Hepatic Impairment
: It is contraindicated in patients with severe hepatic impairment.
Contraindications
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Side Effects & Adverse Reactions
Most common adverse reactions are constipation, nausea and abdominal pain.
Warnings & Precautions
Sphincter of Oddi spasm and Pancreatitis.
Patients who should be monitored closely-
without a gallbladder
with new or worsening abdominal pain
with nausea and vomiting
with acute biliary pain
with liver or pancreatic enzyme elevation
Pharmacology & Mechanism of Action
Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.