Eluxadoline
💊 Brand Formulations & Prices
2 brands sorted by unit price
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesEluxan is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
The recommended dose is 75 mg tablet taken orally twice daily with food. Patients who develop severe constipation for more than 4 days have to discontinue the drug. If a dose is missed, patient should take the next dose at the regular time and avoid taking two doses at a time.
Pediatric Use
: Safety and effectiveness in pediatric patients have not been established.
Hepatic Impairment
: It is contraindicated in patients with severe hepatic impairment.
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Most common adverse reactions are constipation, nausea and abdominal pain.
Sphincter of Oddi spasm and Pancreatitis.
Patients who should be monitored closely-
without a gallbladder
with new or worsening abdominal pain
with nausea and vomiting
with acute biliary pain
with liver or pancreatic enzyme elevation
Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.