Combomin
Cheaper & Alternative Brands
Same generic (Vitamin B1, B6 & B12), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
3 Bion is indicated where a deficiency of the relevant vitamins exists. It is indicated for the treatment of following diseases: Polyneuropathy of any origin such alcoholic or toxiconeuropathies as-diabetic, Neuritis, Neuralgia, Cervical Syndrome, Shoulder-arm syndrome, Lumbago, Sciatica, Myalgia, Intercostal neuralgia, Herpes Zoster, Trigeminal Neuralgia, Supportive treatment in facial paresis.
Dosage & Administration
Tablet: 1-3 Tablets per day or as advised by the physician.
Injection:
In severe (acute) cases
: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
In mild cases
: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.
Use in children: There is no information on the use of this drug in children.
Contraindications
Vitamin B1, Vitamin B6 and Vitamin B12 is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the preparation.
Side Effects & Adverse Reactions
Generally well tolerated but allergic reactions may be observed in few cases.
Warnings & Precautions
Cyanocobalamin should not be given in patients with subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.
Pharmacology & Mechanism of Action
Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression and eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness, tingling and lowers the risk of heart diseases.
The vitamin ingredients are absorbed well in per oral reception. It is widely distributed to most tissues and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body’s requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms of pyridoxal phosphate an pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine.