Phenylephrine Hydrochloride

Vasculex injection is indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.

Dosage & Administration

Dosing for treatment of hypotension during anesthesia
: The recommended initial dose is 40 to 100 mcg administered by intravenous bolus. Additional boluses may be administered every 1-2 minutes as needed; not to exceed a total dosage of 200 mcg in a single administration. Do not use if the solution is colored or cloudy or if it contains particulate matter. Discard any unused portion.

Adverse reactions to Vasculex are primarily attributable to excessive pharmacologic activity. Adverse reactions reported in published clinical studies, observational trials, and case reports of Vasculex are reflex bradycardia, ischemia, hypertension, vomiting, nausea, neck pain & tremors by body system.

Phenylephrine is an α-1 adrenergic receptor agonist. Following Phenylephrine intravenous administration, increases in systolic and diastolic blood pressures and arterial blood pressure are observed. The onset of blood pressure increase is rapid, typically within minutes.
Following phenylephrine hydrochloride intravenous administration, increases in systolic and diastolic blood pressures, mean arterial blood pressure, and total peripheral vascular resistance are observed. The onset of blood pressure increase following an intravenous bolus phenylephrine hydrochloride administration is rapid, typically within minutes. As blood pressure increases following intravenous administration, vagal activity also increases, resulting in reflex bradycardia. Phenylephrine has activity on most vascular beds, including renal, pulmonary, and splanchnic arteries.