OshudDeferasirox
Antidote preparations
Brands & Prices (12)
📋 Indications & Uses⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
Brand Formulations & Prices
12 brands sorted by unit price
Chelova FCT
Chelova
Jadenu
Deferox
Desixen
Ferasirrox
Chelova
Chelova FCT
Desixen
Deferox
Ferasirrox
Jadenu
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesChelova is indicated for the treatment of chronic iron overload due to repeated blood transfusions in adult and pediatric patients aged 2 years and over with thalassaemia, sickle cell disease and myelodysplastic syndrome. Also indicated for treating chronic iron overload in patients with non-transfusion-dependent thalassemia syndromes aged 10 years and older.
Deferasirox is contraindicated in hypersensitivity to the active substance or to any of the excipients. Cannot be given when creatinine clearance is less than 40 ml/min or serum creatinine >2 times the upper limit of normal.
Cytopenias may occur diarrhea, constipation, vomiting, nausea, abdominal pain, abdominal distension, dyspepsia upper gastrointestinal ulceration and hemorrhage have been reported. Headache, dizziness and main
CNS involvement. Elevation of hepatic transaminases may occur. Cases of Stevens-Johnson syndrome (SJS) and skin rash have been rarely reported. Auditory and ocular disturbances may occur.
Fatal and non-fatal gastrointestinal bleeding, ulceration, and irritation may occur during Chelova treatment , Use caution in patients who are taking Chelova in combination with drugs that have known ulcerogenic or hemorrhagic potential, such as NSAIDs, corticosteroids, oral bisphosphonates, and anticoagulants.
Cytopenias, including agranulocytosis, neutropenia and thrombocytopenia have been reported. Monitor blood counts during Chelova therapy.
Serious hypersensitivity reactions have been reported, If reactions are severe, discontinue Chelova and institute appropriate medical intervention.
Deferasirox is an orally active chelator that is highly selective for iron, It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. Deferasirox promotes excretion of iron, primarily in the faeces. Deferasirox has low affinity for zinc and copper, and does not cause constant low serum levels of these metals. In an iron balance metabolic study in iron overloaded adult thalassaemia patients, Deferasirox at daily doses of 10, 20 and 40 mg/kg induced the mean net excretion of 0.119, 0.329, and 0,445 mg Fe/kg body weight/day, respectively.