OshudBempedoic acid
Brands & Prices (6)
📋 Indications & Uses Dosage & Administration⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
Brand Formulations & Prices
6 brands sorted by unit price
Belopid
Bemodic
Bempid
Bemvas
Novelip
Winolip
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesBelopid is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Dosage & AdministrationAdminister 180 mg orally once daily with or without food.
Upper respiratory tract infection
Muscle spasms
Hyperuricemia
Back pain
Abdominal pain or discomfort
Bronchitis
Pain in extremity
Anemia
Elevated liver enzymes
Elevations in serum uric acid have occurred. Assess uric acid levels periodically as clinically indicated. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. Tendon rupture has occurred. Discontinue Belopid at the first sign of tendon rupture. Avoid Belopid in patients who have a history of tendon disorders or tendon rupture.
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is expressed primarily in the liver. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors.