Xanita
Cheaper & Alternative Brands
Same generic (Nitazoxanide), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Adnix is indicated for the treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia and Entamoeba histolytica.
Dosage & Administration
Age 1-3 years
: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days.
Age 4-11 years
: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days.
Age 12 years or above
: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days.
It is recommended to be administered with food.
Contraindications
It is contraindicated in patients with known hypersensitivity to Nitazoxanide or any components of the preparation.
Side Effects & Adverse Reactions
The most frequent side effects, reported by Adnix are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Warnings & Precautions
Adnix must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Pharmacology & Mechanism of Action
Nitazoxanide is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Nitazoxanide is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Nitazoxanide and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.