Wellbac
Cheaper & Alternative Brands
Same generic (Probiotic Combination [4 Billion]), same form (Capsule)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
This is indicated in the following indications-
Diarrhea
Digestive discomfort
Lactose intolerance
Vaginal infection
Antibiotic associated diarrhea
Dosage & Administration
1 or 2 probiotics capsules 3 times daily or as directed by the physician.
Contraindications
The use of probiotics is not advised in patients at risk of opportunistic infections and in those with badly damaged GI tracts.
Side Effects & Adverse Reactions
No known toxicity or side-effects.
Pharmacology & Mechanism of Action
Studies of probiotic activity in recent years provide evidence that probiotics counter experimental and human gastrointestinal inflammation (human inflammatory bowel disease) by their effects on epithelial cell function, including epithelial cell barrier function, epithelial cytokine secretion and their antibacterial effects relating to colonization of the epithelial layer. It reduces gastrointestinal pH through stimulation of lactic-acid-producing bacteria; provide a direct antagonistic action on gastrointestinal pathogens. Moreover it competes with pathogens for binding and receptor sites. In addition, there is emerging evidence that probiotics induce regulatory T cells that act as a break on the effector T cells that would otherwise cause inflammation.
Lactobacillus acidophilus and Bifidobacterium bifidum appear to enhance the nonspecific immune phagocytic activity of circulating blood granulocytes. This effect may account, in part, for the stimulation of IgA responses in infants infected with rotavirus. Lactic acid bacteria, like strains of Lactobacillus acidophilus, Lactobacillus bulgaricus have also demonstrated antioxidant ability. Mechanisms include chelation of metal ions (iron, copper), scavenging of reactive oxygen species and reducing activity.