Topicazole

A-Migel oral gel is indicated-
For the treatment of oral and gastrointestinal candidiasis.
For eradication of fungal colonization in the mouth and gastrointestinal tract.
For the treatment of super infections due to gram-positive bacteria.
A-Migel
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A-Migel oral gel is indicated-
For the treatment of oral and gastrointestinal candidiasis.
For eradication of fungal colonization in the mouth and gastrointestinal tract.
For the treatment of super infections due to gram-positive bacteria.
A-Migel cream is indicated in dermatomycoses, e.g.:
Tinea pedis (Athlete's foot)
Tinea corporis (Tinea circinata)
Tinea manuum
Tinea cruris due to: Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii, Epidermophyton floccosum
Candidial infections
Tinea versicolor.
Infections of the skin (e.g. intertrigo)
Perianal infections
Stomatitis angularis (cheilitis)
Balanoposthitis
Otitis externa
In addition miconazole cream has a very rapid alleviating effect on the pruritis which frequently accompanies infection.

Occasionally nausea and vomiting, diarrhea with long term use and rarely allergic reactions.

If the concomitant use of A-Migel and anticoagulant is considered, the anti-coagulant effect should be monitored and titrated. A-Migel and phenytoin plasma level should also be monitored when used concomitantly. In infants and young children, caution must be taken to ensure that the gel does not obstruct the throat.

Pharmacodynamics
: Miconazole possesses an antifungal activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram-positive bacilli and cocci. Its activity is based on the inhibition of a demethylation step in the ergosterol biosynthesis. Ergosterol, the end-product of the biosynthetic pathway and the main sterol in yeast and fungi. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it. These holes allow the essential constituents of the fungal cells to leak out and ultimately the fungal cells die.
Pharmacokinetics
: The oral bioavailability of Miconazole is low (25-30%) because there is little absorption of Miconazole from the intestinal tract. Miconazole is systemically absorbed after administration as the oral gel. Absorbed Miconazole is bound to plasma proteins (88.2%), primarily to serum albumin and red blood cells (10.6%). The absorbed portion of Miconazole oral gel is largely metabolized; less than 1% of the administered dose is excreted unchanged in the urine. The terminal plasma half-life is 20-25 hours in most patients. The elimination half-life of Miconazole is similar in any renal impaired patient.