Secnid DS

D-Zole is indicated in-
Intestinal Amoebiasis
Hepatic Amoebiasis
Urethritis and vaginitis due to Trichomonas vaginalis
Giardiasis

Secnidazole tablet should be administered orally. The dosage schedule of is mentioned below:
Acute Intestinal Amoebiasis:
Adults
: 2 gm single dose, taken preferably just before meal.
Children
: 30 mg/kg single dose, taken preferably just before meal.
Asymptomatic Amoebiasis (minute& cystic form):
Adults
: 2 gm once daily for only 3 days, taken preferably just before meal.
Children
: 30 mg/kg once daily for only 3 days, taken preferably just before meal.
Hepatic Amoebiasis: Evacuation of pus must be performed simultaneously with Secnidazole treatment at the suppurative stage of hepatic amoebiasis.
Adults
: 1.50 gm/day in a single or divided doses, just before meal, for 5 days.
Children
: 30 mg/kg/day, in a single or divided dose, just before meal, for 5 days.
Giardiasis:
Adults
: 2 gm single dose, taken preferably just before meal.
Children
: 35-50 mg/kg single dose, taken preferably just before meal.
Trichomoniasis:
Adults
: 2 gm single dose, taken preferably just before meal. The partner should also receive the same treatment concomitantly.

The clinical studies have shown that D-Zole is characterized by very good tolerance and no serious adverse reactions have been reported to date. The following side-effects may be observed with D-Zole as with all nitroimidazole derivatives & are rarely serious:
Most frequent side-effects
: Gastrointestinal disturbances, nausea, epigastric pain, metallic taste, glossitis, stomatitis.
Occasional side effects
: Urticaria, moderate leukopenia which is reversible on treatment discontinuation.
Rare side-effects
: Vertigo, ataxia and motor incoordination, paresthesia, peripheral neuropathy. With D-Zole, gastrointestinal disorders e.g. nausea, vomiting, eoigastric pain, etc., have been reported in very rare cases.

Patients should be advised not to take alcohol during treatment with D-Zole (because of the possibility of antabuse effect). Administration of D-Zoleshould be avoided to patients with a history of blood dyscrasia.

Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole. The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Secnidazole gives it the longest half-life of second-generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.