Promtil

Avotil is indicated-
To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions.
Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders.
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Avotil is indicated-
To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions.
Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders.
For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility).
Acute mania.
For the short-term treatment of generalized non-psychotic anxiety.

Antiemetic
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Children (not recommended in children <10 kg or <2 years):
10-14 kg: 2.5 mg every 12-24 hours as needed;maximum: 7.5 mg/day
15-18 kg: 2.5 mg every 8-12 hours as needed;maximum:10 mg/day
19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day.
Adults: 5-10 mg 3-4 times/day;usual maximum:40 mg/day
Antipsychotic
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Children (not recommended in children <10 kg or <2 years):
2-12 years: 2.5 mg 2-3 times/day
Increase dosage as needed to a maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years
Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients for treatment of severe disturbances
Nonpsychotic anxiety
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Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks
Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; increase dosing intervals (twice daily, thrice daily, etc) as necessary to control response or side effects; maximum daily dose should probably not exceed 75 mg in elderly; gradual increases (titration) may prevent some side effects or decrease their severity.
Prochlorperazine may be administered without regard to the meal.

Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the skin or eyes.

Caution should be taken while performing tasks that require alertness, such as driving or using machinery. The use of alcohol can cause extreme drowsiness. This medication may increase sensitivity to sunlight. Prolonged sun exposure should be avoided and sunscreen and protective clothing should be taken when anybody is exposed to the sun. This medication can reduce sweating making it more susceptible to heatstroke.

Prochlorperazine is a dopamine & histamine antagonist. The mechanism of antiemetic activity is due to the blockade of histamine H, & dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. It also has a weak anticholinergic effect and prevents acid reflux by increasing the tone of the lower oesophageal sphincter.