Profen

Advel is indicated in-
Relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis
Treatment of primary dysmenorrhea
Control of mild to moderate pain generally and particularly when pain is associated with inflammation
Reduction of fever
Dental and period pain
Relief of backache
Rheumatic pain
Muscular pain

Ibuprofen Tablet
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1. Mild to moderate pain and fever:
Adults and adolescents >40 kg body weight (12 years and above):
200-400 mg given as a single dose or 3-4 times a day with an interval of 6 hours as required.
In migraine headache, 400 mg should be given as a single dose, if necessary 400 mg with intervals up to 6 hours.
The maximum daily dose should not exceed 1200 mg.
Children 20 kg body weight (6-11 years)
Children 20-29 kg (6-9 years): 200 mg 1-3 times a day with intervals of 6 hours as required.
The maximum daily dose should not exceed 600 mg.
Children 30-90 kg (10-11 years): 200 mg 1-4 times a day with intervals of 6 hours as required.
The maximum daily dose should not exceed 800 mg.
Ibuprofen tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age.
2. Primary dysmenorrhoea:
Adults and adolescents 40 kg body weight (12 years of age and above) 200-400 mg 1-3 times a day, with an interval up to 6 hours, as needed. The maximum daily dose should not exceed 1200 mg.
3. Rheumatic diseases:
Adults: The recommended dose is 1200-1800 mg daily in divided doses. Maintenance doses of 600-1200 mg daily may be effective in some patients. In acute and severe conditions the dose may be (temporarily) increased to a maximum of 2400 mg in 3 or 4 divided doses.
Adolescents from 15 to 17 years of age: The recommended dose should be adjusted by weight: 20 mg/kg to a maximum of 40 mg/kg body weight daily (max 2400 mg daily) in 3 to 4 divided doses.
Ibuprofen SR Capsule
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Adults, the elderly and children & adolescents between 12 and 18 years
Initially one (300 mg) or two (600 mg) Ibuprofen SR capsules should be taken twice daily. Not more than 4 capsules are to be taken in 24 hours.
Ibuprofen SR capsule is not recommended for children below 12 years of age.
Ibuprofen Suspension
: Children-
3-6 months (body-weight over 5 kg): 1/2 tsp (2.5 ml) 3 times daily
6 months-1 year: 0.5 tsp (2.5 ml) 3-4 times daily
1-4 years: 1 tsp (5 ml) 3 times daily
4-7 years: 1.5 tsp (7.5 ml) 3 times daily
7-10 years: 2 tsp (10 ml) 3 times daily
10-12 years: 3 tsp (15 ml) 3 times daily
Not recommended for children weighing less than 5 kg.
In juvenile rheumatoid arthritis; up to 30-40 mg/kg of body weight daily in 3-4 divided doses may be taken.

The most common side effects are headache, somnolence, vertigo, fatigue, agitation, dizziness, insomnia, irritability and gastrointestinal ulcer.

Patients on long term therapy with Advel require ocular monitoring at regular intervals, as changes in ocular function have been reported. Patients with SLE are more likely than others to develop hypersensitivity to Advel. Advel should be prescribed with caution in patients with asthma.

Ibuprofen has a high level of anti-inflammatory, anti-pyretic, and analgesic activity. The analgesic effects of Ibuprofen are due to both a peripheral and a central effect. Ibuprofen is a potent inhibitor of the enzyme cyclooxygenase, which thus results in a marked reduction in prostaglandin synthesis. Ibuprofen also inhibits the synthesis of some lipo-oxygenase products. Ibuprofen thus quickly relieves pain and stiffness, reduces swelling, and improves the movement of different joints of arthritis sufferers.