Prindol
Generic: Pridinol Mesilate
Daily Dose:
Duration:
Cheaper & Alternative Brands
Same generic (Pridinol Mesilate), same form (Tablet)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Prindol is indicated for the treatment of muscle tension/spasm (central and peripheral muscle spasms), neck spasm (torticollis), low back pain (lumbago) and general muscle pain.
Dosage & Administration
The recommended dose is 1.5-3 mg pridinol 3 times daily. The administration is independent of meals, with the onset of the effect being faster when the medicine is taken before a meal. However, if the patient suffers from low blood pressure, take the tablets after meals to reduce the risk of fainting. Or as directed by the registered physician.
Use in Children and Adolescents: No data are available on the use of Pridinol in children and adolescents.
Contraindications
Hypersensitivity to the active substance or to any of the excipients, glaucoma, prostate hypertrophy, syndrome with urinary retention, gastrointestinal obstructions, arrhythmia, first trimester of pregnancy.
Side Effects & Adverse Reactions
Common side effects
: Abdominal pain, arrhythmias, asthenia, dizziness, dry mouth, headache, hypotension and nausea.
Rare side effects
: Impaired ability to focus, impaired vision, diarrhea, vomiting, hypersensitivity reactions such as itching, redness of the skin, swelling or shortness of breath, impaired attention, coordination, taste, anxiety and depression.
Warnings & Precautions
Use with caution in the elderly, patients with liver or kidney problems and hypotension as the risk of circulatory problems (fainting) may be increased. Prindol contains lactose, so, patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Pharmacology & Mechanism of Action
Central Muscle Relaxant Effect: Pridinol primarily targets the Central Nervous System (CNS). It acts on the brainstem and the spinal cord, where it selectively inhibits polysynaptic reflexes. In simple terms, when a muscle is injured or strained, the nervous system sends continuous, hyperactive signals causing the muscle to stay locked in a painful contraction (spasm). Pridinol dampens these overactive reflexes, effectively blocking the excessive neurological signals traveling from the spine to the muscles. This allows the skeletal muscles to relax and reduces localized tension.
Anticholinergic (Antimuscarinic) Action: Pridinol possesses distinct antimuscarinic properties. It acts as an antagonist to acetylcholine, a primary neurotransmitter responsible for triggering muscle contractions. By blocking the muscarinic acetylcholine receptors- It directly counters the chemical signals that trigger muscle spasms in both smooth and skeletal muscles. This specific action is also why it helps reduce muscle rigidity and tremors associated with parkinsonism.