Permival
Generic: Fluphenazine + Nortriptyline
Daily Dose:
Duration:
Alternatives (10)Cheaper & Alternative Brands
Same generic (Fluphenazine + Nortriptyline), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Amival is indicated in-
Mild to moderate mixed anxiety/depression
Emotional disturbance
Sleep disorder
Gastric problems
Dosage & Administration
Adults: One tablet 2 to 3 times daily.
Contraindications
It is contraindicated in :
History of gradual epilepsy or organic brain damage
Blood dyscrasia
Severe cardiac insufficiency
Renal or liver damage
Patients taking monoamine oxidase inhibitor (MAOI)
Younger children
Hypersensitivity to any component of the preparation
Side Effects & Adverse Reactions
Tardive dyskinesias have been reported in phenothiazine therapy; usually after prolonged courses given at doses adequately to control psychotic illness. Blood dyscrasia, Malignant Neuroleptic syndrome and sudden death have been reported rarely. Agranulocytosis is a rare but potentially fatal adverse effect of Nortriptyline Hydrochloride.
Warnings & Precautions
Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction, and in concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.
Pharmacology & Mechanism of Action
Nortriptyline hydrochloride
is a tricyclic antidepressant. Nortriptyline inhibits the uptake of norepinephrine and serotonin at nerve terminals. In contrast to its parent compound amitriptyline which is equally potent in inhibiting the uptake of norepinephrine and serotonin, Nortriptyline has a greater effect on norepinephrine reuptake than on serotonin reuptake.
Fluphenazine
is a tranquilizer of the phenothiazine type with piperazine side chain. Fluphenazine primarily acts as a neuroleptic drug whose main therapeutic effect is believed to reside in potent dopamine (specially D2) receptor antagonism.