Pemast
Cheaper & Alternative Brands
Same generic (Pemirolast Potassium), same form (Ophthalmic Solution)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Mirolast ophthalmic solution is indicated for the prevention of itching of the eye due to allergic conjunctivitis.
Dosage & Administration
Adult
: 1 to 2 drops in each affected eye four times daily.
Pediatric Use
: Safety and effectiveness in pediatric patients below the age of 3 years have not been established.
Contraindications
Pemirolast ophthalmic solution is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients of this product.
Side Effects & Adverse Reactions
Burning of eye, dry eye, ocular discomfort, non ocular allergy, sinusitis, headache and sneezing or nasal congestion.
Warnings & Precautions
To prevent contaminating the dropper tip and solution, do not touch the eyelids or surrounding areas with the dropper tip. Keep the bottle tightly closed when not in use Patients should be advised not to wear contact lens if their eye is red Mirolast should not be used to treat contact lens related irritation Patients should wait 10 minutes after applying Mirolast before they insert contact lenses
Pharmacology & Mechanism of Action
Pemirolast binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolast has also been observed to inhibit antigen-stimulated calcium ion influx into mast cells through the blockage of calcium channels. Pemirolast inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.