OTO-Plus
Dose Regimen:
Course Duration:
Alternatives (2)Cheaper & Alternative Brands
Same generic (Chloramphenicol + Lidocaine Hydrochloride), same form (Ear Drop)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Acute bacterial ear infections
Dosage & Administration
Otic/Aural Otitis externa
: Instill 2-3 drops into the ear bid-tid.
Contraindications
History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.
Side Effects & Adverse Reactions
Ototoxicity.
Warnings & Precautions
Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.
Pharmacology & Mechanism of Action
Chloramphenicol
inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Lidocaine
is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.