Opthamet
Cheaper & Alternative Brands
Same generic (Antazoline + Tetryzoline), same form (Ophthalmic Solution)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Temporary relief of the signs and symptoms of allergic conjunctivitis including conjunctival hyperaemia, chemosis and itching in adults and children above 2 years of age.
Dosage & Administration
Adults and adolescents
: 1 drop 2 to 3 times daily upto 14 days.
Children (Older than 2 years of age)
: No specific studies are available in this patient group. For possible systemic effects, the dosage should exceed to 1 to 2 drops per day.
Children (Below 2 years of age)
: Not to be used in children below 2 years of age.
The eye drop should not be used for longer periods than 14 days as this may cause rebound hyperemia and toxic follicular conjunctivitis.
Contraindications
Known hypersensitivity to Antazoline/ Tetryzoline or to any of the excipients. Concomitant use with Monoamine Oxidase Inhibitors (MAOI).
Side Effects & Adverse Reactions
The most common adverse effect is burning/stinging upon installation, which is mild and transient in nature.
Warnings & Precautions
The eye drop should be used with caution in elderly patients with severe cardiovascular disease, including arrhythmia, poorly controlled hypertension or diabetes.
Pharmacology & Mechanism of Action
Antazoline is an anti-histamine of the ethylenediamine class, which are selective HI-antagonist. Effects mediated by HI receptors include the contraction of smooth muscle and the dilation and increased permeability of the capillaries. Tetryzoline is a sympathomimetic with alpha-adrenergic activity. Its vasoconstrictive effect reduces redness and edema in allergic conjunctivitis. Antihistamines, which act by blocking the HI histamine receptor, are highly effective in providing relief of itching but are not very active in relieving the associated redness. The use of products combining an anti-histamine and a vasoconstrictor is well established in the symptomatic relief of allergic eye disease.