Olonase
Cheaper & Alternative Brands
Same generic (Mometasone Furoate + Olopatadine Hydrochloride), same form (Nasal Spray)Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Momelo nasal spray is indicated for the treatment of symptoms of seasonal allergic rhinitis in adult and pediatric patients 6 years of age and older.
Contraindications
Hypersensitivity to any component of Olopatadine Hydrochloride and Mometasone Furoate Nasal Spray.
Side Effects & Adverse Reactions
Common side effects are-
Dysgeusia
Epistaxis
Nasal discomfort
The following clinically significant adverse reactions are described-
Local Nasal Adverse Reactions
Somnolence and Impaired Mental Alertness
Glaucoma and Cataracts
Hypersensitivity Reactions
Immunosuppression and Risk of Infections
Hypercorticism and Adrenal Suppression
Warnings & Precautions
Epistaxis, nasal ulcerations, nasal septal perforations, impaired wound healing, and Candida albicans infection: Monitor patients periodically for signs of adverse reactions on the nasal mucosa.
Somnolence
: Avoid engaging in hazardous occupations requiring complete mental alertness and motor coordination such as driving or operating machinery when taking this nasal spray.
Avoid concurrent use of alcohol or other central nervous system (CNS) depressants with this nasal spray because additional reductions in alertness and additional impairment of CNS performance may occur.
Glaucoma and cataracts
: Monitor patients with a change in vision or with a history of increased intraocular pressure, glaucoma, and/or cataracts.
Hypersensitivity Reactions
: Hypersensitivity reactions can occur with this nasal spray. Hypersensitivity reactions including wheezing, have occurred after the nasal administration of mometasone furoate. Discontinue this nasal spray if such reactions occur.
Immunosuppression and Risk of Infections
: Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex. More serious or even fatal course of chickenpox or measles in susceptible patients: Use caution in patients with the above because of the potential for worsening of these infections.
Hypercorticism and adrenal suppression with misuse or use of higher- than-recommended dosages or at the regular dosage in susceptible patients at risk for such effects.
Potential reduction in growth velocity in children
: Routinely monitor the growth in pediatric patients receiving this nasal spray.
Pharmacology & Mechanism of Action
This is a metered-dose manual nasal spray unit containing an aqueous suspension of a fixed-dose combination of a olopatadine hydrochloride and mometasone furoate monohydrate.
Olopatadine is a histamine-1 (H1) receptor inhibitor. The antihistaminic activity of olopatadine has been documented in isolated tissues, animal models, and humans.
Mometasone furoate is a corticosteroid demonstrating potent anti-inflammatory activity. The precise mechanism of corticosteroid action on allergic rhinitis is not known. Corticosteroids have been shown to have a wide range of inhibitory effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.