Nysol
Cheaper & Alternative Brands
Same generic (Nystatin), same form (Oral Suspension)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Candex is an antifungal antibiotic active against a wide range of yeasts and yeast like fungi including Candida albicans. It is used for the prevention and treatment of Candida infections of oral cavity, esophagus and intestinal tract. It provides effective prophylaxis against oral candidiasis in those born of mothers with vaginal candidiasis. It is used for the prophylaxis of Candida overgrowth during courses of broadspectrum antibiotics.
Dosage & Administration
Children:
In intestinal and oral candidiasis (thrush):
1,00,000 units (1 ml) should be dropped into the mouth four times daily.The longer the suspension is kept in contact with the affected area in the mouth, before swallowing, the greater will be its effect.
For prophylaxis in the newborn:
The suggested dose is 1,00,000 units (1 ml) once daily or as prescribed by the physician.
Adult:
For the treatment of intestinal or esophageal candidiasis:
5,00,000 units (5 ml) by mouth 3 or 4 times daily. The dose may be doubled, if required.
For prophylaxis of intestinal candidiasis in adults:
10,00,000 units (10 ml) daily.
For prophylaxis to suppress the over growth of Candida albicans in patients receiving broad spectrum antibiotic therapy:
10,00,000 units (10 ml) daily.
For the treatment of dental sores and oral infection:
1,00,000 units (1 ml) suspension should be dropped into the mouth four times daily.
Elderly: Older people with intestinal candidiasis who are unable to swallow tablets should be given 5,00,000 units (5 ml) suspension four times daily.
Contraindications
There is no known contraindication to the use of Nystatin.
Side Effects & Adverse Reactions
Nausea, vomiting and diarrhoea have occasionally been reported with high doses of Candex. No systemic effects or allergic reactions have been associated with its oral dose.
Warnings & Precautions
Absorption from the gastrointestinal tract is negligible, therefore no special precaution is required to apply in pregnancy and lactation.
Pharmacology & Mechanism of Action
Nystatin is an antifungal antibiotic. Which has fungistatic or fungicidal activity against variety of pathogenic and nonpathogenic yeast and fungi, including Candida albicans. Nystatin exerts its antifungal activity by binding to sterols in the fungal cell membrane. As a result of binding, the membrane is no longer able to function as a selective barrier, and potassium and other cellular constituents are lost. It is poorly absorbed from the gastrointestinal tract.