NPH
Cheaper & Alternative Brands
Same generic (Hydrocortisone + Neomycin Sulphate + Polymixin B), same form (Ear Drop)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Hydrocortisone, Neomycin Sulphate & Polymixin B ear drops are indicated for the treatment of bacterial ear infections. It will not work for other types of ear infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.
Dosage & Administration
Adults and children over 3 years old: Apply 3 drops into the affected ear up to four times a day, for up to 7 days. Make sure you finish the course of this drop which your doctor has prescribed.
Administrations-
Shake the closed bottle gently before each use
Clean and dry the ears
Do not use soap, it may stop the medicine working
Do not put the drops in your eyes.
Contraindications
Contraindicated-
if you are allergic (hypersensitive) to polymyxin B sulphate, neomycin sulphate, hydrocortisone or any of the other ingredients of this preparation.
if you are allergic (hypersensitive) to aminoglycoside antibiotics such as framycetin, kanamycin or gentamicin
if you have a perforated ear drum
if you have either a viral, fungal or tubercular (TB) infection
for a child under 3 years old.
Side Effects & Adverse Reactions
The following side effects rarely may happen with this medicine: seem to get worse instead of better, become red, scaly and itchy.
Warnings & Precautions
Caution should be taken if you have kidney problems. If you have a long-standing infection of your outer ear.
Pharmacology & Mechanism of Action
Polymyxin B sulphate and neomycin sulphate belong to a group of medicines called antibiotics. They kill the germs that can cause ear infections. The anti-infective components in the combination are included to provide action against specific organisms susceptible to them. Neomycin sulfate and polymyxin B sulfate together are considered active against the following microorganisms: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. This product does not provide adequate coverage against Serratia marcescens and streptococci, including Streptococcus pneumoniae.
Hydrocortisone belongs to a group of medicines called steroids. It helps to reduce the swelling and irritation caused by the infection. Hydrocortisone suppress the inflammatory response to a variety of agents and they may delay healing. Since Hydrocortisone may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.