Natrol plus
Cheaper & Alternative Brands
Same generic (Sodium Cromoglicate + Xylometazoline Hydrochloride), same form (Nasal Spray)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Antazol Plus nasal spray is indicated for the prophylaxis and treatment of allergic rhinitis (such as hay fever and perennial rhinitis) where this is accompanied by nasal congestion.
Contraindications
Contraindicated in patients with a known hypersensitivity to any ingredients of the preparation.
Side Effects & Adverse Reactions
No serious side effects have been reported. Occasional irritation of the nasal mucosa may occur during the first day of use. In rare cases with Sodium Cromoglicate solutions alone wheezing and tightness of the chest has been reported. Because a lower dose of Xylometazoline is employed in Antazol Plus it causes mild side effects such as nasal irritation, dryness of the nose, sneezing, headache, insomnia, drowsiness and palpitations.
Warnings & Precautions
The prolonged use or abuse of decongestants in general may lead to rebound congestion or drug induced rhinitis.
Pharmacology & Mechanism of Action
Xylometazoline Hydrochloride
is a sympathomimetic agent with alpha-adrenergic activity. It produces vasoconstriction thus reducing nasal congestion. This enables patients suffering from colds to breathe more easily through the nose.
Sodium Cromoglicate
usually acts through a local effect on the nasal mucosa. It prevents release of the mediators of type-l allergic reactions, including histamine and slow reacting substance of anaphylaxis (SRS-A) from sensitized mast cells after the antigen-antibody union has taken place. The drug does not inhibit the binding of IgE and the specific antigen; instead it suppresses the release of substances (e.g., histamine, SRS-A) in response to this reaction. The drug also inhibits Type-III (late allergic, Arthers) reactions to a lesser extent.