Naftol

Naftol is indicated in the treatment of benign prostatic obstruction and benign prostatic hyperplasia (BPH) associated lower urinary tract symptoms (LUTS). It does not decrease the size of the prostate.

Naftopidil should be taken orally after meal. Swallow it as a whole without crushing or chewing it. In general, for adults, start with Naftopidil 25 once a day. If the effect is insufficient, the dosage may be gradually increased to 50 to 75 mg once a day at intervals of 1 to 2 weeks. The dosage may be adjusted according to age or symptoms. The maximum daily dose is 75 mg.
Hepatic impairment
: Dosage adjustment may be required in severe hepatic impairment as this can affect the metabolism of the drug.
Renal impairment
: Dosage adjustment is not required in patients with renal impairment.
Use in children and adolescents
: Safety and effectiveness have not been established in patients below 18
years of age.

The most common side effects are dizziness, headache, tiredness, blurry vision and stomach discomfort.

Caution should be taken in patients with salt imbalance or orthostatic hypotension and diabetes before taking the medication. This medicine should be used with caution due to the increased risk of temporary loss of consciousness caused by a sudden decrease in the blood pressure.

Naftopidil is a selective a-i adrenergic receptor antagonist with higher antagonistic effect on aiD receptor. It works by relieving smooth muscle tension in urethra and prostate gland so urine is passed more easily. It also suppresses the overactivity of detrusor muscle.