Nafodil
Generic: Naftidrofuryl Oxalate
Daily Dose:
Duration:
Alternatives (1)Cheaper & Alternative Brands
Same generic (Naftidrofuryl Oxalate), same form (Capsule)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Azelto capsule is used to treat peripheral vascular disorders (blood circulation problems outside the brain and heart). It is used to treat the following symptoms of these disorders:
Intermittent claudication
Cramps in legs at night
Severe pain in legs while resting (rest pain)
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Azelto capsule is used to treat peripheral vascular disorders (blood circulation problems outside the brain and heart). It is used to treat the following symptoms of these disorders:
Intermittent claudication
Cramps in legs at night
Severe pain in legs while resting (rest pain)
Pale or blue fngers or toes which get worse when it is cold
Numbness, tingling or burning feelings in fngers or toes (Raynaud’s syndrome or acrocyanosis)
Open sores on the legs or feet (trophic ulcers)
Poor circulation caused by diabetes (diabetic arteriopathy)
To treat gangrene
Dosage & Administration
One or two Naftidrofuryl oxalate capsules three times daily during meals for a minimum of three months or at the discretion of the physician.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Patients with a history of hyperoxaluria or recurrent calcium-containing kidney stones.
Side Effects & Adverse Reactions
Gastrointestinal disorders (uncommon): Diarrhoea, nausea, vomiting and epigastric pain.
Renal and urinary disorders (very rare): Calcium oxalate kidney stones.
Skin and subcutaneous tissue disorders (uncommon): Skin rash.
Hepatobiliary disorders (rare): Liver damage.
Warnings & Precautions
The administration of Azelto may modify the composition of the urine, promoting the formation of calcium oxalate kidney stones. The administration of Azelto without liquid before going to bed may cause local oesophagitis. Therefore, it is essential to always take the capsule with a sufficient amount of water. Cases of liver damage have been reported.
Pharmacology & Mechanism of Action
Naftidrofuryl oxalate possesses a 5HT2-blocking activity and counteracts both the vasoconstrictor effect and the effect promoting platelet aggregation due to serotonin. Naftidrofuryl oxalate has a direct effect on intracellular metabolism. Thus it increases ATP level, decreases lactic acid level in ischemic conditions and enhances the cellular oxidative capacity. Also, Naftidrofuryl oxalate is a powerful spasmolytic agent.