Mecobal
Cheaper & Alternative Brands
Same generic (Mecobalamin), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Colamin tablet is indicated in-
Peripheral neuropathy
Diabetic neuropathy
Alcoholic neuropathy
Drug induced neuropathy
Entrapment neuropathy
Lumbago
Intercostal neuralgia
Diabetic retinopathy
Multiple sclerosis
Vertebral syndrome
Parkinson's disease
Alzheimar's disease
Bell's palsy
Colamin Injection is indicated in-
The treatment of peripheral neuropathies megaloblastic anemia due to vitamin B12 deficiency.
Dosage & Administration
Tablet
: 0.5 mg tablet 3 times daily after meal. The dosage should be adjusted according to age of patient’s and the severity of the symptoms.
Injection
:
Peripheral Neuropathies: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. The dose may be adjusted depending on the patient's age and symptoms.
Megaloblastic Anemia: Adult: 1 ampoule (Mecobalamin 500 mcg) daily, administered IM or IV 3 times a week. After 2 months of medication, the dose should be reduced to a single administration of 1 ampoule at 1 to 3 month intervals for maintenance therapy.
Use in Children
: Not Recommended.
Contraindications
Hypersensitivity to Mecobalamin or other components of the formulation.
Side Effects & Adverse Reactions
Dermatologic Effects: Rash; In the event of such symptoms, treatment should be discontinued.
Gastrointestinal Effects: Anorexia, nausea/vomiting and diarrhea.
Neurologic Effects (Central nervous system): Headache.
Others:
Anaphylactoid reaction: decrease in blood pressure or dyspnea, may occur. Patients should be carefully observed. In the event of such symptoms, treatment should be discontinued immediately and appropriate measures taken.
Hot sensation
Diaphoresis
Pain/induration at the site of intramuscular injection
Warnings & Precautions
Colamin should not be used aimlessly for more than one month unless it is effective. The prolonged use of larger doses of Colamin is not recommended for patients whose occupation requires the handling of mercury or mercury compounds.
Pharmacology & Mechanism of Action
Mecobalamin is one of the two coenzyme forms of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. It is a cofactor in the enzyme methionine synthase which functions to transfer methyl groups for the regeneration of methionine from homocysteine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. Mecobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves, promotes axonal transport and has neuroprotective activity.