Mebendox
Cheaper & Alternative Brands
Same generic (Mebendazole), same form (Chewable Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Helben is indicated for the treatment of threadworms, whipworms, roundworms and hookworms.
Dosage & Administration
Adult and Child over 2 years-
Threadworms
: 100 mg or 1 teaspoonful: Single dose.
Whipworms, Roundworms, Hookworms
: 100 mg or 1 teaspoonful: Twice daily for 3 days.
If reinfection occurs the second dose may be needed after 2 weeks.
Contraindications
Mebendazole is contraindicated in patients with known hypersensitivity to Mebendazole, or to any component of the formulation.
Side Effects & Adverse Reactions
Gastrointestinal: Transient symptoms of abdominal pain and diarrhoea in case of massive infection and expulsion of worms.
Hypersensitivity: Rash, urticaria and angioedema have been observed on rare occasions.
Central Nervous System: Very rare cases of convulsions have been reported.
Haematologic: Neutropenia and agranulocytosis.
Warnings & Precautions
General
: Periodic assessment of organ system functions, including haematopoietic and hepatic, is advisable during prolonged therapy.
Information for Patients
: Patients should be informed of the potential risk to the foetus in women taking Helben during pregnancy, especially during the first trimester. Patients should also be informed that cleanliness is important to prevent reinfection & transmission of the infection.
Pharmacology & Mechanism of Action
Mebendazole is a synthetic broad-spectrum anthelmintic that is active against most nematodes and some other worms. Mebendazole is principally used in the treatment of intestinal nematode infection. Mebendazole inhibits the formation of the worms' microtubules and causes the worms' glucose depletion. After oral administration about 2-10% of oral dose is absorbed from Gl tract and peak plasma concentration occurs within 30 minutes to 7 hours. Mebendazole is highly bound to plasma protein. Elimination half-life is 2.8 to 9 hours.