Maxbuten DS
Cheaper & Alternative Brands
Same generic (Ceftibuten Dihydrate), same form (Powder for Suspension)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Butibac is indicated for the treatment of individuals with mild-to-moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Acute Bacterial Exacerbations of Chronic Bronchitis
: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including (β-lactamase producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only).
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Butibac is indicated for the treatment of individuals with mild-to-moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Acute Bacterial Exacerbations of Chronic Bronchitis
: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including (β-lactamase producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only).
Acute Bacterial Otitis Media
: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including β-lactamase producing strains) or Streptococcus pyogenes.
Pharyngitis and Tonsillitis
: Due to Streptococcus pyogenes.
Dosage & Administration
Otitis Media-
Adult Dosage
: 400 mg orally every 24 hours for 10 days
Pediatric Dosage
: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Tonsillitis/Pharyngitis-
Adult Dosage
: 400 mg orally every 24 hours for 10 days
Pediatric Dosage
: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Bronchitis-
Adult Dosage
: 400 mg orally every 24 hours for 10 days
Pediatric Dosage
: >12 years: 400 mg orally every 24 hours for 10 days
Cystitis-
Adult Dosage
: 400 mg orally every 24 hours for 7 days
Pediatric Dosage
: >12 years: 400 mg orally every 24 hours for 7 days
Pneumonia-
Adult Dosage
: 200 mg orally every 12 hours for 7 to 14 days
Pediatric Dosage
: >12 years: 200 mg orally every 12 hours for 7 to 14 days
Sinusitis-
Adult Dosage
: 400 mg orally every 24 hours for 10 to 14 days
Pediatric Dosage
: >12 years: 400 mg orally every 24 hours for 10 to 14 days
Urinary tract Infection-
Adult Dosage
: 400 mg orally every 24 hours for 10 days
Pediatric Dosage
: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Contraindications
Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Side Effects & Adverse Reactions
Nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, vomiting.
Warnings & Precautions
As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. The dose of Butibac may require adjustment in patients with varying degrees of renal insufficiency. Butibac should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.
Pharmacology & Mechanism of Action
Ceftibuten is the dihydrate salt of Ceftibuten, is a semi-synthetic Cephalosporin antibiotic for oral administration. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.