Lumiface
Cheaper & Alternative Brands
Same generic (Trifarotene), same form (Cream)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Lumiface cream is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.
Dosage & Administration
Apply a thin layer of Trifarotene cream to the affected areas once daily, in the evening, on clean and dry skin. The use of a moisturizer is recommended as frequently as needed from the initiation of treatment. Avoid contact with the eyes, lips, paranasal creases, mucous membranes. Trifarotene cream is intended for topical use only. Not for oral, ophthalmic or intravaginal use.
Side Effects & Adverse Reactions
Most common adverse reactions (incidence >1%) in patients treated with Lumiface cream were application site irritation, application site pruritus, and sunburn.
Warnings & Precautions
Skin irritation
: Patients using Lumiface cream may experience erythema, scaling, dryness and stinging/burning. Maximum severity of these reactions typically occurred within the first 4 weeks of treatment, and severity decreased with continued use of the medication. Depending upon the severity of these adverse reactions, instruct patients to use a moisturizer, reduce the frequency of application of Lumiface cream, or suspend use temporarily. If severe reactions persist the treatment may be discontinued. Avoid application of Lumiface cream to cuts, abrasions, or eczematous or sunburned skin. Use of "waxing" as a depilatory method should be avoided on skin treated with Lumiface cream.
Ultraviolet Light and Environmental Exposure
: Minimize unprotected exposure to ultraviolet rays (including sunlight and sunlamps) during treatment with Lumiface cream. Warn patients who normally experience high levels of sun exposure and those with inherent sensitivity to sun to exercise caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.
Pharmacology & Mechanism of Action
Trifarotene is an agonist of retinoic acid receptors (RAR), with particular activity at the gamma subtype of RAR. Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation. The exact process by which Trifarotene ameliorates acne is unknown.