Lacitab
Cheaper & Alternative Brands
Same generic (Lacidipine), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Lacicard is indicated for the treatment of hypertension, either alone or in combination with other antihypertensive agents such as beta-blockers and diuretics.
Dosage & Administration
Initially 2 mg as a single daily dose, preferably in the morning; increased after 3-4 weeks to 4 mg daily, then if necessary to 6 mg.
Contraindications
Hypersensitivity to dihydropyridine derivatives. Cardiogenic shock, aortic stenosis, avoid within 1 month of myocardial infarction, impaired left ventricular function, pregnancy and breast-feeding.
Side Effects & Adverse Reactions
Flushing, palpitation, edema, headache, dizziness, rarely gastro-intestinal disturbances, gum hyperplasia, aggravation of angina, mood disturbances, asthenia, polyuria, muscle cramps, skin rash (including pruritus and erythema).
Warnings & Precautions
Cardiac conduction abnormalities, poor cardiac reserve, hepatic impairment, withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops, avoid grapefruit juice (may affect metabolism).
Pharmacology & Mechanism of Action
Lacidipine inhibits the influx of calcium into smooth muscle cells by the competitive inhibition of voltage-dependent calcium 'L' channels. This action results in the inhibition of the effects triggered by the influx of calcium into the cells, such as the activation of the contractile proteins in smooth muscle.