Klinkof-D
Daily Dose:
Course Duration:
Alternatives (7)Cheaper & Alternative Brands
Same generic (Diphenhydramine + Dextromethorphan + Levomenthol), same form (Syrup)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
This syrup is indicated as an antitussive, for the relief of persistent, dry, irritating cough and aids restful sleep.
Dosage & Administration
Adults and children over 12 years
: 2 teaspoonfuls of syrup 4 times a day or as directed by the physicians. Do not take more than 8 teaspoonfuls of syrup in 24 hours.
Use in children & Adolescents
: The efficacy and safely of Dextromethorphan Hydrobromide have not been established in pediatric patients and adolescents.
Contraindications
This syrup is contraindicated in individuals with known hypersensitivity to the product or any of its components. This medicine is contraindicated in individuals who are taking, or have taken, monoamine oxidase inhibitor within the preceding two weeks. Dextromethorphan, In common with other centrally acting antitussive agents, should not be given to subjects in, or at risk of developing respiratory failure.
Side Effects & Adverse Reactions
This syrup may cause drowsiness, dizziness, nausea, vomiting, gastrointestinal disturbance, dry mouth, nose and throat difficulty in urination, or blurred vision.
Warnings & Precautions
This syrup may cause drowsiness; if affected, individuals should not drive or operate machinery. Diphenhydramine Hydrochloride should not be taken by individuals with narrow-angle glaucoma or symptomatic prostatic hypertrophy. Caution is particularly recommended for adolescents and young adults as well as in patients with a history of drug abuse or psychoactive substances.
Pharmacology & Mechanism of Action
Dextromethorphan Hydrobromide is a non-opioid antitussive drug. It exerts its antitussive activity by acting on the cough center in the medulla oblongata, raising the threshold for the cough reflex. Levomenthol has mild local anesthetic and decongestant properties. Diphenhydramine Hydrochloride possesses antitussive, antihistaminic, anticholinergic properties.