Imojev
Generic: Encephalitis Vaccine
Daily Dose:
Course Duration:
Cheaper & Alternative Brands
Same generic (Encephalitis Vaccine), same form (SC Injection)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Imojev is indicated for active immunisation against Japanese encephalitis in adults, adolescents, children and infants aged 2 months and older. Imojev should be considered for use in individuals at risk of exposure through travel or in the course of their occupation.
Contraindications
Hypersensitivity to the active substance or to any of the excipients or to the residues protamine sulphate, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein. Individuals who show hypersensitivity reactions after receiving the first dose of the vaccine should not be given the second dose. Administration must be postponed in persons with acute severe febrile conditions.
Side Effects & Adverse Reactions
Very common
: headache, muscle pain, injection site pain, injection site tenderness, tiredness.
Common
: Nausea, influenza like illness, fever, other injection site reactions (e.g. redness, hardening, swelling, itching).
Uncommon
: vomiting, skin rash, changes in the lymph-nodes, migraine (throbbing headache, often accompanied by nausea and vomiting and sensitivity to light), dizziness, vertigo (spinning sensation), diarrhoea, belly pain, excessive sweating, itching, chills, general condition of feeling unwell, musculoskeletal stiffness, joint pain, weakness, abnormal laboratory liver test results (hepatic enzymes increased).
Pharmacology & Mechanism of Action
The mechanism of action of Japanese encephalitis (JE) vaccines is not well understood. Studies in animals have shown that the vaccine triggers the immune system to produce antibodies against Japanese encephalitis virus that are most often protective. Challenge studies were performed in mice that were treated with human Encephalitis Vaccine antisera. These studies showed that almost all mice that had a Plaque Reduction Neutralization Test titre of at least 1:10 were protected from a lethal Japanese encephalitis virus challenge.