Gentabac HC
Cheaper & Alternative Brands
Same generic (Gentamicin + Hydrocortisone Acetate), same form (Ear Drop)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Genmax HC is indicated for the treatment of chronic suppurative otitis media, otitis externa and as prophylactic treatment of otitis externa following trauma. Genmax HC ear drops is also indicated for post-operative local use in surgery to infected mastoid cavities.
Contraindications
This is contraindicated in patients with known or suspected perforation, or where there is a risk of perforation of the tympanic membrane. This Ear Drops should not be used to treat viral infections of the external ear canal unless it is suspected that there is a secondary bacterial infection present which will respond to topical Gentamicin. Known hypersensitivity to Hydrocortisone or Gentamicin or any other components of the product.
Side Effects & Adverse Reactions
Ear discomfort, ear irritation may occur in rare cases. Gentamicin may cause irreversible partial or total deafness when given systemically or when applied topically to open wounds or damaged skin.
Warnings & Precautions
This Ear Drops should be discontinued at the first appearance of any sign of local or general hypersensitivity. Long-term continuous therapy should be avoided. Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If an infection is not improved after one week, cultures and susceptibility tests should be performed to verify the identity of the organism and to determine what alternative therapy should be installed. In severe infections, this Ear Drops should be supplemented with appropriate systemic antibiotic treatment.
Pharmacology & Mechanism of Action
Gentamicin is an aminoglycoside antibiotic and has a bactericidal action against many Gram-negative and some strains of Gram-positive bacteria. After actively transporting across the bacterial cell membrane, Gentamicin binds to a specific receptor protein on the 30S subunit of bacterial ribosomes, and interferes with an initiation complex between mRNA and the 30S subunit, inhibiting protein synthesis. DNA may be misread, thus producing nonfunctional proteins; polyribosomes are split apart and are unable to synthesize protein. Hydrocortisone depresses formation, release, and activity of endogenous mediators of inflammation as well as modifying immune response.