Dexagen L

Dexagen L ophthalmic solution is indicated for prevention and treatment of inflammation and prevention of infection associated with cataract surgery in adults.

The most commonly reported non-serious adverse reactions are eye irritation, ocular hypertension and headache. An increase of intra-ocular pressure (IOP) of eyes and glaucoma may occur. Diabetics are also more prone to develop subcapsular cataracts following prolonged topical steroid administration. There are some possible adverse reactions related to cornea as like thinning of the cornea, perforation in some cases in cornea.

This eye drop is for ocular use only. Prolonged use may induce antibiotic resistance with the result of overgrowth of non-susceptible organisms, including fungi. If an infection develops, the treatment should be discontinued and alternative therapy used. Prolonged use of topical ophthalmic corticosteroids may result in ocular hypertension/glaucoma but this is unlikely when This eye drop is used for the recommended treatment period (7 days).

Levofloxacin is a synthetic third-generation fluoroquinolone anti-bacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin, the active L-isomer of ofloxacin that inhibits bacterial type II topoisomerases-DNA gyrase and topoisomerase IV. Levofloxacin preferentially targets DNA gyrase in Gram-negative bacteria and topoisomerase IV in Gram-positive bacteria. On the other hand, the action of Dexamethasone Phosphate is to inhibit the phospholipase A 2 , the first step in prostaglandin synthesis. Also, inhibits the chemotactic infiltration of neutrophils into the site of inflammation. Its anti-inflammatory activity is 30 times greater and its overall therapeutic effectiveness 8-10 times greater than that of hydrocortisone. Like other glucocorticoids, it is anti-allergic, anti-exudative & anti-proliferative.