Darbetin
Cheaper & Alternative Brands
Same generic (Darbepoetin Alfa), same form (IV/SC Injection)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Darbagen is indicated for the treatment of anemia due to:
Chronic Kidney Disease (CKD) in patients on dialysis and patients not on dialysis.
The effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.
Contraindications
Uncontrolled hypertension
Pure Red Cell Aplasia (PRCA)
Serious allergic reactions
Side Effects & Adverse Reactions
Hypertension, stroke, thromboembolic events, convulsions, allergic reactions, rash/erythema and Pure Red Cell Aplasia (PRCA).
Warnings & Precautions
Darbagen should be used with caution in patients with controlled hypertension, seizures, Pure Red Cell Aplasia (PRCA) or suspected allergy to the product.
Pharmacology & Mechanism of Action
Darbepoetin alfa is an erythropoiesis-stimulating protein that is produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology. It is a 165-amino acid protein that differs from recombinant human erythropoietin in containing 5 N-linked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. The 2 additional N-glycosylation sites result from amino acid substitutions in the erythropoietin peptide backbone.