Cosmotrin

Cosmotrin 0.1% cream is indicated for the treatment of Pregnancy-Related Abdominal Striae (Stretch Marks). It is also indicated for the topical treatment of acne vulgaris, mottled hyperpigmentation, photo damaged skin, flat warts and other skin conditions eg. icthyosis vulgaris, keratosis follicularis.
Cosmotrin 0.025% cream is indicated for topical application in the treatment of acne vulgaris in which comedones, papules and pustules predominate.

This cream should be applied sparingly to the whole affected area once or twice daily. The skin should be thoroughly cleaned and dried before application. Patient should be advised that 6 to 8 weeks of treatment may be required before a therapeutic effect is observed. Moisturizers and cosmetics may be used during treatment with Tretinoin cream but should not be applied to the skin at the same time. Astringent toiletries should be avoided.

Initial external application of Cosmotrin generally may cause burning or slight irritation, erythema and peeling at the site of application may also occur. If irritation becomes severe and persists, discontinue application and consult your physicians, if necessary.

Avoid contact of Cosmotrin with lips, mouth, eyes, eyelids, nostrils or another mucous membrane. If contact in these areas occurs, careful washing with water is recommended. Apply the cream to sensitive areas of skin, such as the neck, with caution. Do not use it on broken, eczematous or sun burned skin.

Although the exact mode of action of Tretinoin is unknown, current evidence suggests that topical Tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally Tretinoin stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones, papules and pustules.