Carfilez

Carfilez is a proteasome inhibitor that is indicated:
For the treatment of adult patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy in combination with Lenalidomide and dexamethasone; or Dexamethasone; or Daratumumab and dexamethasone; or Daratumumab and hyaluronidase-fihj and dexamethasone; or Isatuximab and dexamethasone.
As a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy.

Hydration
: Adequate hydration is required prior to dosing in Cycle 1, especially in patients at high-risk of tumor lysis syndrome (TLS) or renal toxicity. Consider hydration with both oral fluids (30 mL per kg at least 48 hours before Cycle 1, Day 1) and intravenous fluids (250 mL to 500 mL of appropriate intravenous fluid prior to each dose in Cycle 1). If needed, give an additional 250 mL to 500 mL of intravenous fluids following Carfilzomib administration. Continue oral and/or intravenous hydration, as needed, in subsequent cycles. Monitor patients for evidence of volume overload and adjust hydration to individual patient needs, especially in patients with or at risk for cardiac failure.
Premedications and Concomitant Medications
: Premedicate with the recommended dose of dexamethasone for monotherapy or dexamethasone administered as part of the combination therapy. Administer dexamethasone orally or intravenously at least 30 minutes but no more than 4 hours prior to all doses of Carfilzomib during Cycle 1 to reduce the incidence and severity of infusion-related reactions. Reinstate dexamethasone premedication if these symptoms occur during subsequent cycles. Provide thromboprophylaxis for patients being treated with Carfilzomib in combination with other therapies. Consider antiviral prophylaxis to decrease the risk of herpes zoster reactivation.
Electrolyte Monitoring
: Monitor serum potassium levels regularly during treatment with Carfilzomib.

The most common adverse reactions occurring in at least 20% of patients treated with Carfilez in monotherapy trials: anemia, fatigue, thrombocytopenia, nausea, pyrexia, dyspnea, diarrhea, headache, cough, edema peripheral.
The most common adverse reactions occurring in at least 20% of patients treated with Carfilez in the combination therapy trials: anemia, diarrhea, hypertension, fatigue, upper respiratory tract infection, thrombocytopenia, pyrexia, cough, dyspnea, and insomnia.

Cardiac Toxicities
: Monitor for signs and symptoms of cardiac failure or ischemia. Withhold Kyprolis and evaluate promptly.
Acute Renal Failure
: Monitor serum creatinine regularly.
Tumor Lysis Syndrome (TLS)
: Administer pre-treatment hydration. Monitor for TLS, including uric acid levels and treat promptly.
Pulmonary Toxicity, including Acute Respiratory Distress Syndrome, Acute Respiratory Failure, and Acute Diffuse Infiltrative Pulmonary Disease
: Withhold Kyprolis and evaluate promptly.
Pulmonary Hypertension
: Withhold Kyprolis and evaluate.
Dyspnea
: For severe or life-threatening dyspnea, withhold Kyprolis and evaluate.
Hypertension, including Hypertensive Crisis
: Monitor blood pressure regularly. If hypertension cannot be controlled, interrupt treatment with Kyprolis.
Venous Thrombosis
: Thromboprophylaxis is recommended.
Infusion-related Reactions
: Premedicate with dexamethasone.
Hemorrhage
: Fatal or serious cases of hemorrhage may occur, including gastrointestinal, pulmonary, and intracranial hemorrhage. Promptly evaluate signs and symptoms of blood loss.
Thrombocytopenia
: Monitor platelet counts; interrupt or reduce Kyprolis dosing as clinically indicated.
Hepatic Toxicity and Hepatic Failure
: Monitor liver enzymes regularly. Withhold Kyprolis if suspected.
Thrombotic Microangiopathy
: Monitor for signs and symptoms. Discontinue Kyprolis if suspected.
Posterior Reversible Encephalopathy Syndrome (PRES)
: Consider neuro-radiological imaging (MRI) for onset of visual or neurological symptoms; discontinue Kyprolis if suspected.
Progressive Multifocal Leukoencephalopathy
: Consider PML if new or worsening neurologic manifestations. Discontinue Kyprolis in patients who develop PML. Increased Fatal and Serious Toxicities in Combination with Melphalan and Prednisone in Newly Diagnosed Transplant-Ineligible Patients.
Embryo-Fetal Toxicity
: Kyprolis can cause fetal harm. Advise females of reproductive potential and males with female partners of reproductive potential of potential risk to a fetus and to use effective contraception.

Carfilzomib is a tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds to the N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core particle within the 26S proteasome. Carfilzomib had antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. In animals, carfilzomib inhibited proteasome activity in blood and tissue and delayed tumor growth in models of multiple myeloma, hematologic, and solid tumors.