Arotrix-C

Arotrix-C lotion is indicated for the treatment of scabies and pruritus. Moreover, it is used for the relief of itching and skin irritation like as sunburn, dry eczema, itchy dermatitis, allergic rashes, hives, nettle rash, chickenpox, insect bite and stings, heat rashes and personal itching.

In scabies patients, skin discomfort, usually described as burning, stinging or tingling occurs in a few individuals soon after the lotion is applied. Other transient signs and symptoms of irritation including erythema, edema, eczema and rash which may follow the treatment of scabies with Permethrin and Crotamiton lotion are generally considered to be the part of the natural history of scabies.

Nursing staff, who routinely apply Permethrin and Crotamiton lotion, may wear gloves to avoid any possible irritation to the hands. Avoid contact with the eyes. The lotion can cause eye irritation. If lotion goes to the eye, rinse with water immediately.

This is a combination of Permethrin which is a photostable synthetic pyrethroid that possesses a broad spectrum of insecticidal activity and low mammalian toxicity and Crotamiton which is used to treat scabies infection. It is also used to relieve the itching of certain skin conditions.
Mode of action
: The insect rapidly absorbs Permethrin via mouth, respiratory tract or the intact cuticle. Although the primary target tissue is the nervous system, insects are not killed by dysfunction of a single organ but by a complex series of reactions in various organs, such as metabolic exhaustion and paralysis of the nervous system. Permethrin primarily affects sodium channels in the nerve membrane and causes prolongation of the transient increase in sodium permeability associated with membrane depolarization. After treatment with permethrin, the sodium current is evoked by a step depolarization of the membrane. This leads to sensory hyperexcitability, incoordination and prostration. It is assumed that mode of action against mites is similar.
Pharmacokinetics
: The only approved route of administration is the topical route and there are few human data available on systemic exposure or kinetics following permethrin application to the skin. Some presystemic metabolism occurs in skin. Less than 0.5% of applied permethrin is absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized by ester hydrolysis, most likely in the liver and the products are excreted primarily in the urine. Crotamiton penetrates rapidly into human skin. Low but measurable concentrations of crotamiton are found in plasma, with a maximum level after 4-10 hours, declining rapidly thereafter.