Apalene
Cheaper & Alternative Brands
Same generic (Adapalene), same form (Cream)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Aclene cream or gel is indicated for topical treatment of acne vulgaris.
Contraindications
Adapalene should not be administered to individuals who are hypersensitive to Adapalene or any of its components.
Side Effects & Adverse Reactions
Erythema, scaling, dryness, pruritus, burning sensation, skin irritation, stinging unburn, acne flares, etc. are commonly seen during the first month of therapy but usually lessen with continued use of the medication.
Warnings & Precautions
Aclene should not be applied to cuts, abrasions, eczematous or sunburned skin.
Pharmacology & Mechanism of Action
Adapalene acts on retinoid receptors that are commonly found in the skin of face, back and chest. Biochemical and pharmacological studies have demonstrated that Adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of that represent important features in the pathology of acne vulgaris. Adapalene binds with specific retinoic acid nuclear receptors that normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Absorption of Adapalene through human skin is low.