Ametrol-VT
Generic: Metronidazole + Miconazole Nitrate
Daily Dose:
Duration:
Cheaper & Alternative Brands
Same generic (Metronidazole + Miconazole Nitrate), same form (Vaginal Tablet)No other brands currently registered with this exact active generic and dosage form.
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Vaginal treatment of female urogenital trichomonas infection, prevention & local therapy of candidiasis.
Dosage & Administration
In trichomoniasis, concurrently with oral metronidazole treatment and 1 vaginal tablet should be inserted high up into the vagina once a day (preferably before going to bed at night) for 10 days. Long-term recovery may be expected only is response to the simultaneous oral treatment of both partners.
In candidiasis or other fungal infections, 1 vaginal tablet has to be inserted high up into the vagina for 10 days. The vaginal tablet should be slightly moistened before application.
Contraindications
Hypersensitivity; hepatic impairment (oral gel). Porphyria.
Side Effects & Adverse Reactions
Nausea, vomiting, febrile reactions, rash, drowsiness, diarrhoea, anorexia and flushing, hepatitis. Local irritation and sensitisation, contact dermatitis.
Warnings & Precautions
For external use only; discontinue if sensitization or irritation occurs. Pregnancy and lactation
Pharmacology & Mechanism of Action
Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.