Acilog Mix
Generic: Biphasic Insulin Aspart
Daily Dose:
Course Duration:
Alternatives (1)Cheaper & Alternative Brands
Same generic (Biphasic Insulin Aspart), same form (SC Injection)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
Acilog Mix (rDNA) injection is indicated to improve glycemic control in adults and children with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
Contraindications
Biphasic Insulin Aspart (rDNA) is contraindicated
During episodes of hypoglycemia
In patients with hypersensitivity to Insulin Aspart or any of its excipients.
Side Effects & Adverse Reactions
Side effects of Insulin Aspart are hypoglycemia, lipodystrophy, weight gain, peripheral edema.
Warnings & Precautions
Dose adjustment and monitoring
: Blood glucose should be monitored in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision.
Renal or hepatic impairment
: Reduction in the Insulin Aspart dose may require in these cases.
Pharmacology & Mechanism of Action
30% Insulin Aspart and 70% Insulin Aspart Protamine (rDNA) is a human insulin analog suspension containing 30 % soluble Insulin Aspart and 70% Insulin Aspart Protamine crystals. This is a blood glucose lowering agent with an earlier onset and an intermediate duration of action. Insulin Aspart is homologous with regular human insulin with the exception of a single substitution of the proline by aspartic acid in position B28, and is produced by recombinant DNA technology utilizing Saccharomyces cerevisiae (baker’s yeast).
Primary function of insulin, including Insulin Aspart, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, primarily by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.