A-Zyme
Cheaper & Alternative Brands
Same generic (Pancreatin), same form (Tablet)
Clinical Prescribing Information
Medical monograph and safety information for healthcare professionals & patients.Indications & Clinical Uses
A-Zyme is employed for the treatment of patients with
Chronic pancreatitis
Cystic fibrosis/Mucoviscidosis
Following partial or complete pancreatectomy
Total gastrectomy
Steatorrhea
Somatostatinoma
Celiac disease and
Other conditions associated with pancreatic insufficiency
Dosage & Administration
2-3 tablets to be swallowed whole with little water immediately after or during meal. Or as directed by the physician
Contraindications
Pancreatin is contraindicated in patients with known hypersensitivity to the drug.
Side Effects & Adverse Reactions
The most frequent side effects are gastrointestinal including nausea, vomiting and abdominal discomfort. Buccal and perianal soreness may occur, particularly in infants. Hypersensitivity reactions manifested by sneezing, lacrimation or skin rashes have been reported.
Warnings & Precautions
Patients known to be allergic to animal protein should be treated with caution.
Pharmacology & Mechanism of Action
Pancreatin is a preparation of Pancreatin, an extract from mammalian pancreas containing enzymes with Amylase, Protease and Lipase activity. It is designed to disintegrate in the alkaline medium of the duodenum where it releases the active enzyme components of Pancreatin (Amylase, Protease and Lipase). Amylase hydrolyzes dietary starch to yield maltose, maltoriose and a-dextrin. Protease cleaves peptide bonds in the center of proteins and polypeptides and forms amino acids and oligopeptides. Lipase hydrolyzes dietary triglycerides forming two molecules of fatty acid and a molecule of beta-monoglyceride. It converts not less than 25 times its weight of starch into soluble carbohydrates and not less than 25 times its weight of casein into proteoses within 5 mins, (equivalent to 150 times in 30 mins).