Vonoprazan
💊 Brand Formulations & Prices
64 brands sorted by unit price
Provon
Arena
Bygerd
Kenzo
Novonil
Ornova
Pcab
Prazan
Provon
Unigerd
VZ-20
Venocid
Vinca
Vini
Vonion
Vonity
Vonix
Voniza
Vonliv
Vono
Vonocab
Vonofast
Vonofix
Vonolend
Vonomax
Vonopa
Vonosil
Vonotop
Vonover
Vonozan
Vontac
Vopran
Xevon
Arena
Bygerd
Kenzo
Novonil
Ornova
Pcab
Prazan
Unigerd
Venocid
Vinca
Vini
Vonion
Vonity
Vonix
Voniza
Vonliv
Vono
Vonobest
Vonocab
Vonofast
Vonofix
Vonolend
Vonomax
Vonopa
Vonosil
Vonotem
Vonotop
Vonover
Vonozan
Vontac
Vopran
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesArena is indicated for:
Gastric ulcer, duodenal ulcer, reflux esophagitis, prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration, prevention of recurrence of gastric or duodenal ulcer during NSAID administration.
Adjunct to Helicobacter pylori eradication in the following: Gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer or Helicobacter pylori gastritis.
Vonoprazan is contraindicated in:
Patients with hypersensitivity to Vonoprazan or to any excipient of the product.
Patients receiving atazanavir sulphate, nelfinavir or rilpivirine hydrochloride.
Following side effects have been reported with the use of Arena: Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, gamma-glutamyl transferase increased, AST increased, Liver function test abnormal, ALT increased, ALP increased, LDH increased, y-GPT increased, edema and eosinophilia
At the treatment, the course of the disease should closely be observed and the minimum therapeutic necessity should be used according to the disease condition. In the long-term, treatment with Arena, close observation by such means as endoscopy should be made.
In the maintenance of healing of reflux esophagitis, Arena should be administered only to the patients who repeat recurrence and recrudescence of the condition. Administration to the patients who do not necessitate maintenance of healing should be avoided.
When the healing is maintained over a long period and when there is no risk of recurrence, the dose reduction to a dose of 10mg from a dose 20mg, or suspension of administration should be considered.
Vonoprazan is a potassium competitive acid blocker (P-CAB) and does not require activation by acid. It inhibits H
+
, K
+
-ATPase in a reversible and potassium-competitive manner. Vonoprazan has a strong basicity and resides on the acid production site of gastric parietal cells for a long time, thereby inhibiting gastric acid production. Vonoprazan exerts a strong inhibitory effect on formation of mucosal damage in upper part of the gastrointestinal tract.