Ursodeoxycholic Acid

Antigall is indicated for the treatment of-
Cholestasis (Jaundice)
Viral Hepatitis
Alcoholic Fatty Liver
Primary Billiary Cirrhosis (PBC)
Primary Sclerosing Cholangitis (PSC)
Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

Dosage & Administration

Dissolution of Gall stones
: 8-12 mg/kg/day either as single night time dose or in divided doses.
Primary Billiary Cirrhosis
: 10-15 mg/kg/day in 2-4 divided doses.
Acute Viral Hepatitis
: 600 mg/day.
Alcoholic Fatty Liver
: 300 mg/day.
Primary Sclerosing Cholangitis
: 25-30 mg/kg/day.
Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis
: 13-15 mg/kg/day.

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.

Ursodeoxycholic Acid is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Ursodeoxycholic Acid is achieved through a decrease in secretion of cholesterol in bile. Ursodeoxycholic Acid achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.
Therefore, alters bile composition from supersaturated to unsaturated. Ursodeoxycholic Acid also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Ursodeoxycholic Acid improves cholestatic liver diseases by-
Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids
Stimulating hepatobilliary secretion
Protecting hepatocytes against bile acid-induced apoptosis
Ursodeoxycholic Acid is completely absorbed in the upper intestine. Time to peak serum concentration varies from 30 to 150 minutes. The rate of absorption ranges from 60-80%. After absorption Ursodeoxycholic Acid enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Ursodeoxycholic Acid appear in the circulation and very small amounts are excreted into urine. The biologic half life of Ursodeoxycholic Acid ranges from 3.5-5.8 days.