Nikethamide
💊 Brand Formulations & Prices
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📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesNikethamide is indicated in-
Acute respiratory failure
Respiratory depression following anesthesia
CNS depression
2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide.
Porphyria, epilepsy or other convulsive disorders, perebral oedema, airways obstruction, cerebrovascular accident, severe hypertension & ischemic heart diseases.
Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness. Cardiovascular side effects inlude Iteration of blood pressure & cardiac arrhythmia. Over dosage may cause nausea, vomiting & diarrhoea.
It should not used in less severe degrees of hypertension or impaired cardiac reverse & hepatic dysfunction.
Nikethamide also known as nicotinic acid diethylamide is a central & respiratory stimulant. It has direct stimulatory action on CNS, increases the frequency & depth of breathing. It has no immediate impact on the cardiovascular system. It is extensively metabolized in liver. All metabolites & a small amount of unchanged drug is excreted in urine.