Flurbiprofen
💊 Brand Formulations & Prices
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📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesPain and inflammation in rheumatic disease and other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, frozen shoulder, low back pain, sprains and strains; mild to moderate pain including dysmenorrhoea; migraine; postoperative analgesia, dental pain; relief of sore throat.
Active peptic ulceration or recent gastrointestinal hemorrhage, ulcerative colitis, Bronchospasm and other hypersensitivity-type reactions with aspirin and other non-steroidal agents. Relative contraindications are anticoagulant therapy, diuretic therapy and patients with a history of heart failure/hypertension and non-allergic asthma. Patients with a prior hypersensitivity to Flurbiprofen or any other ingredient in the formulation.
The most important ones are peptic ulceration, hemorrhage and perforation. Gastrointestinal adverse effects include: dyspepsia, nausea, vomiting, constipation and diarrhea. There may be peripheral edema due to salt and water retention. Some neurological reactions such as dizziness, tinnitus, deafness and blurred vision have been reported which have disappeared on withdrawal of the drug.
Urbifen has not been extensively studied in children. It is not recommended for children under the age of 12 years.
Flurbiprofen is a cyclooxygenase inhibitor which has potent anti-inflammatory effects with antipyretic and analgesic activity. It inhibits prostaglandin and thromboxane biosynthesis. It inhibits vasodilatation and also prevents the sensitization of pain fibers by prostaglandins.
Flurbiprofen is readily absorbed (>95%) after oral administration. Peak serum concentration is observed at 1.5 hour and its apparent half life is 2-6 hour. It is extensively protein bound (99%). The amount absorbed is not significantly different when taken before or after food. Approximately 95% of a dose is excreted in the urine within 24 hours. Small amounts are excreted in breast milk. There is no evidence of accumulation of the drug.