Etoricoxib

174 Registered Brands From ৳4.00 / unit ⚕️ Non-steroidal Anti-inflammatory Drugs (NSAIDs)

💊 Brands & Prices (174) 📋 Indications & Uses 💊 Dosage & Administration ⚠️ Contraindications ⚡ Side Effects & Adverse Reactions 🛡️ Warnings & Precautions 🔬 Pharmacology & Mechanism

💊 Brand Formulations & Prices

174 brands sorted by unit price

📖 Official Clinical Monograph

DGDA Approved Prescribing Guidelines

📋 Indications & Uses

Alcox tablet is indicated for the symptomatic relief of-
Osteoarthritis (OA)
Rheumatoid arthritis (RA)
Ankylosing spondylitis, and
The pain and signs of inflammation associated with acute gouty arthritis.
For the short-term treatment of moderate pain associated with dental surgery.

💊 Dosage & Administration

Adult and adolescent over 16 years:
Osteoarthritis
: The recommended dose is 30 mg once daily. In some patients with insufficient relief from symptoms, an increased dose of 60 mg once daily may increase efficacy.
Rheumatoid arthritis
: The recommended dose is 90 mg once daily.
Ankylosing spondylitis
: The recommended dose is 90 mg once daily.
Acute gouty arthritis
: The recommended dose is 120 mg once daily. In clinical trials for acute gouty arthritis, Etoricoxib was given for 8 days.
Postoperative dental surgery pain
: The recommended dose is 90 mg once daily, limited to a maximum of 3 days.
Some patients may require additional postoperative analgesia. As the cardiovascular risks of Etoricoxib may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis.

⚠️ Contraindications

Hypersensitivity to the active substance or to any of the excipients.
Active peptic ulceration or active gastro-intestinai (Gl) bleeding.
Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors.
Pregnancy and lactation.
Severe hepatic dysfunction (serum albumin <25 g/l or Child-Pugh score 10).
Estimated renal creatinine clearance <30 ml/min.
Children and adolescents under 16 years of age.
Inflammatory bowel disease.
Congestive heart failure (NYHA ll-IV).
Patients with hypertension whose blood pressure is persistently elevated above 140/90 mmHg and has not been adequately controlled.
Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease.

⚡ Side Effects & Adverse Reactions

Side-effects may include palpitation, fatigue, influenza-like symptoms, ecchymosis; less commonly dry mouth, taste disturbance, mouth ulcer, appetite and weight change, atrial fibrillation, transient ischaemic attack, chest pain, flushing, cough, dyspnoea, epistaxis, anxiety, mental acuity impaired, paraesthesia, electrolyte disturbance, myalgia and arthralgia; very rarely confusion and hallucinations.

🛡️ Warnings & Precautions

Caution is advised with treatment of patients most at risk of developing a gastrointestinal complication with NSAIDs; the elderly, patients using any other NSAID or acetylsalicylic acid concomitantly or patients with a prior history of gastrointestinal disease, such as ulceration and Gl bleeding.
Patients with significant risk factors for cardiovascular events (e.g. hypertension, hyperlipidaemia, diabetes mellitus, smoking) should only be treated with Alcox after careful consideration.
Administration of Alcox may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, and thereby impair renal function. Monitoring of renal function in such patients should be considered.
Caution should be exercised in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension and in patients with pre-existing edema from any other reason.
Any patients with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormalliver function test has occurred, should be monitored. If signs of hepatic insufficiency occur, or if persistently abnormal liver function tests (three times the upper limit of normal) are detected, Alcox should be discontinued.
Alcox should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Alcox may mask fever and other signs of inflammation. Caution should be exercised when co-administering Alcox with warfarin or other oral anticoagulants.

🔬 Pharmacology & Mechanism

Etoricoxib is a potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor within, and significantly above, the clinical dose range. Two isoforms of cyclooxygenase have been identified: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is responsible for prostaglandin-mediated normal physiologic functions such as gastric cytoprotection and platelet aggregation. Inhibition of COX-1 by nonselective NSAIDs has been associated with gastric damage and inhibition of platelet aggregation. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by etoricoxib (within the clinical dose range) decreases these clinical signs and symptoms with decreased potential for Gl toxicity and effects on platelet aggregation. Etoricoxib produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150 mg daily. Etoricoxib did not inhibit gastric prostaglandin synthesis.

Etoricoxib

💊 Brand Formulations & Prices

Coxitor

Oricox

Etofax

Etoricoxib

Etoricoxib

Etovan

Ribox

SB-Eto

Temcox

Algirex

Artorix

Cox-E

CoxTop

Coxetori

Coxsafe

Danilo

E-coxib

Eflam

Eto

Etonil

Etonov

Etorica

Etoricoxib

Etoriflex

Etorix

Etoshine

Etoxib

Etrib

Exib

Fabetor

Kingcox

Neocox

Oricox

Recox

Riox

Starcox

Torcox

Vericox

Coxfree

Ecox

Eroflam

X Dol

Rito

Setorib

Coxia

Coxitor

Etocox

Aroxia

Tory

Coxpain

Etox

Eto

Ezepain

G-Cox

Rofin

Espana

Etofax

Etoricoxib

Etoricoxib

Etovan

Etoricoxib

Temcox

Alcox

Algirex

AmiCoxib

Artorix

Cox-E

CoxTop

Coxbest

Coxet

Coxetori

Coxsafe

Danilo

E-coxib

Eflam

Etnaaf

Eto

Etoben